Sensing Environmental Lipids by Dendritic Cell Modulates Its Function

Sensing environmental lipids by dendritic cell modulates its function.

Because of its oxidative modification during the acute-phase response to an aggression, low density lipoprotein (LDL) can be regarded as a source of lipid mediators that can act both to promote and inhibit inflammation. This can be exemplified by the production of anti-inflammatory oxidized fatty acids and proinflammatory lysophosphatidylcholine (LPC) during LDL oxidation. We have shown previou...

Cell Modulates Its Function Sensing Environmental Lipids by Dendritic

Sensing Lipids with Mincle: Structure and Function

Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity through its capacity to recognize a wide range of lipidic species derived from damaged/altered self and foreign microorganisms. Self-ligands include sterols (e.g., cholesterol), and β-glucosylceramides, and the protein SAP130, which is released upon cell death. Foreign lipids comprise those from both m...

Activation of Toll-like receptor-2 by tumor associated matrix metalloproteinase-2 modulates dendritic cell function

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases which degrade extracellular matrix proteins and modulate cell proliferation, migration, differentiation and angiogenesis. MMP-2, a member of the gelatinase subfamily of MMPs, participates in the remodeling and resolution of tissue injury and tumorigenesis. We recently identified an unexpected new role for MMP2 in the modulation ...

Optimizing dendritic cell function by genetic modification.

The potential for effective immune therapy for cancer has been met with considerable enthusiasm because of a number of fundamental advances in our understanding of the immune responses to cancer. First, previous questions about the existence of tumor antigens have largely been answered, since tumorassociated and tumor-specific antigens clearly exist and, when they are recognized by antigen-spec...